CORDIS Project
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This project investigates how the arrangement of aquaporin transmembrane channels affects their ability to transport water. It focuses on the human AQP5 aquaporin, exploring its behavior in different lipid environments using advanced simulation techniques.
The goals of this proposal are to (i) determine how does the oligomerization state of aquaporin (AQP) transmembrane channels influence the water transport properties of these channels, and to (ii) understand how aquaporins’ association and transport properties change under different lipid composition conditions.
The study will be conducted on the human AQP5 aquaporin, whose atomistic high resolution structure has been recently determined.
First we will determine the water transport properties of…
UNIVERSITA DEGLI STUDI DI CAGLIARI
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