CORDIS Project
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This project investigates how proteins in the Bcl-2 family regulate cell death by controlling mitochondrial membrane permeability. By quantifying interactions within this protein network and modeling the signaling pathways, it aims to enhance understanding of cancer cell survival mechanisms and identify potential thera…
The proteins of the Bcl-2 family function as key regulators of apoptosis by controlling the permeabilization of the mitochondrial outer membrane.
They form an intricate, fine-tuned interaction network which is altered in cancer cells to avoid cell death.
Currently, we do not understand how signaling within this network, which combines events in cytosol and membranes, is orchestrated to decide the cell fate.
The main goal of this proposal is to unravel how apoptosis signaling is integrated by t…
EBERHARD KARLS UNIVERSITAET TUEBINGEN
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