CORDIS Project
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The ApoptoMDS project investigates how deregulated cell death signaling in blood stem cells contributes to bone marrow failure and myelodysplastic syndromes, potentially leading to acute myeloid leukemia. It aims to understand the mechanisms of apoptosis resistance and explore therapeutic strategies to improve patient…
Deregulated apoptotic signaling in hematopoietic stem and progenitor cells (HSPCs) strongly contributes to the pathogenesis and phenotypes of congenital bone marrow failure and myelodysplastic syndromes (MDS) and their progression to acute myeloid leukemia (AML). HSPCs are highly susceptible to apoptosis during bone marrow failure and early MDS, but AML evolution selects for apoptosis resistance.
Little is known about the main apoptotic players and their regulators.
ApoptoMDS will investigate th…
UNIVERSITAETSKLINIKUM FREIBURG
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