CORDIS Project
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This project aims to investigate the role of the Apolipoprotein E gene in metabolic syndrome, particularly focusing on how different alleles affect metabolism. By studying both animal models and human populations, it seeks to identify mechanisms that could lead to new prevention or treatment strategies.
Metabolic Syndrome (MetS) is closely linked to disturbances in lipid and glucose metabolism and increases the risk of developing cardiovascular disease and diabetes.
One-fourth of the adult European population has the MetS and a further increase is anticipated because a greater prevalence of obesity in the future.
Apolipoprotein E (APOE) associates with lipoproteins and mediates theirmetabolism.
In humans, the APOE gene is polymorphic and has three alleles, APOE*2, APOE*3 and APOE*4.
Carrying th…
INSTITUTO ARAGONES DE CIENCIAS DE LA SALUD
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