CORDIS Project
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This project investigates the role of specific enzymes in causing genomic instability in cancer. By studying genetically modified mice, the research aims to understand how cytosine deamination contributes to tumor progression and develop tools for cancer treatment.
Genomic instability is a key hallmark of cancer.
Chromosome translocations require the formation of pairs of double-strand breaks (DSB) and trans-chromosomal ligation of the broken ends.
Members of the AID/APOBEC family of enzymes deaminate cytosine (C) to uracil (U) in the context of a polynucleotide substrate.
Excision of the U residue from DNA produces an abasic site, leading to incision of the DNA strand containing the abasic site by the conventional base-excision repair pathway.
The introdu…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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