CORDIS Project
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This research focuses on the spindle assembly checkpoint and its role in regulating chromosome segregation during cell division. By studying the activity of the anaphase promoting complex in live cells, the project aims to clarify the mechanisms governing mitotic progression.
The spindle assembly checkpoint (SAC) inhibits chromosome segregation and mitotic exit prior to biorientation of all chromosomes on the mitotic spindle by restraining the activity of the anaphase promoting complex or cyclosome (APC/C) towards Cyclin B1 and Securin.
In contrast, other APC/C substrates like Cyclin A2 bypass this inhibition and are degraded in the presence of an active SAC.
Despite its central role in mitotic progression, the molecular mechanisms activating the APC/C towards differ…
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