CORDIS Project
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This project investigates how CD8 T cells recognize antigens from the Toxoplasma gondii parasite, which can cause severe illness. It aims to understand the mechanisms of antigen processing and T cell activation, with the goal of developing effective vaccines against toxoplasmosis.
Antigen recognition by CD8 T cells enables us to combat infectious pathogens, such as viruses and parasites.
This feature represents the groundwork for vaccine efficacy.
Immune surveillance is achieved by screening short peptides presented by major histocompatibility complex (MHC) class I molecules on the surface of infected cells.
Recognition of foreign peptide-MHC I complexes triggers cytokine production and cytotoxicity towards the infected target. CD8 T cells are key for protection against i…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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