CORDIS Project
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This project investigates the RNA interference mechanism in insects, focusing on how it mediates antiviral responses against viruses. By utilizing various scientific approaches, the research aims to uncover the systemic propagation of antiviral signals and the role of double-stranded RNA uptake in mosquito immunity.
RNA interference (RNAi) is a conserved sequence-specific, gene-silencing mechanism that is induced by double-stranded RNA (dsRNA).
One of the functions of this pathway is the defense against parasitic nucleic acids: transposons and viruses.
Previous results demonstrated that viral infections in Drosophila melanogaster are fought by an antiviral RNAi response and that components of the endocytic pathway are required for dsRNA entry to initiate the RNAi response.
Recently we have shown that infect…
INSTITUT PASTEUR
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