CORDIS Project
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This project investigates the role of Developmental Endothelial Locus-1 (Del-1) in regulating leukocyte adhesion during inflammation, particularly in eye conditions. It aims to explore Del-1's potential as a therapeutic target and its involvement in the body's response to tissue hypoxia.
Leukocyte recruitment is an important component of inflammatory and autoimmune disorders and consists of selectin-mediated rolling, the chemokine-induced activation of leukocytes, the integrin-dependent firm adhesion and the subsequent transendothelial migration. LFA-1 is an important leukocyte integrin mediating adhesion by binding to its endothelial counter-receptors ICAM-1 and -2.
Whereas many adhesion receptors are known to promote leukocyte recruitment, very little information exists about…
TECHNISCHE UNIVERSITAET DRESDEN
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