CORDIS Project
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This project investigates how the tumor microenvironment, specifically cancer-associated fibroblasts, contributes to drug resistance in colorectal cancer. By exploring mechanotransduction pathways, the research aims to identify biomarkers for patient stratification and develop therapies that target these fibroblasts to…
Refractory tumors and emergence of drug resistance are the most important challenges in cancer therapeutics.
The non-cancerous determinants of therapeutic response and particularly the role of the tumor microenvironment (TME) in resistance are poorly understood. I previously described the crucial role of cancer-associated fibroblasts (CAFs) in key tumorigenic processes, including matrix remodeling, cancer cell invasion and growth.
Importantly, these aggressive CAF phenotypes are controlled by me…
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
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