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ANTIBIOCLICKS aims to combat antibiotic resistance by developing new antibiotic delivery methods using natural siderophore-antibiotic conjugates. The project focuses on understanding the chemical mechanisms that allow these conjugates to enter bacteria, potentially leading to novel treatments for resistant infections.
The frightening increase in antibiotic drug resistance is threatening global healthcare as we know it.
To this extent the World Health Organisation that has classes M. tuberculosis and Gram-negative nosocomial infections as the highest priority for novel R&D strategies. A major obstacle to drug discovery programs is to design inhibitors that can efficiently enter into bacteria.
One such stealth strategy is exemplified by natural siderophore-antibiotics conjugates (sideromycins) that piggyback th…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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