CORDIS Project
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This project aims to determine the structures and functions of calcium-activated chloride channels, which are crucial for various physiological processes. By employing advanced techniques in biochemistry and electrophysiology, it seeks to uncover their mechanisms and develop potential therapeutic strategies.
Calcium-activated chloride channels (CaCCs) play key roles in a range of physiological processes such as the control of membrane excitability, photoreception and epithelial secretion.
Although the importance of these channels has been recognized for more than 30 years their molecular identity remained obscure.
The recent discovery of two protein families encoding for CaCCs, Anoctamins and Bestrophins, was a scientific breakthrough that has provided first insight into two novel ion channel archit…
University of Zurich
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