CORDIS Project
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This project focuses on developing new antibiotics targeting the bacterial sliding clamp, DnaN, to combat antimicrobial resistance. It aims to optimize a previously discovered inhibitor, WAM-N17, and evaluate its effectiveness against multidrug-resistant bacteria.
The bacterial sliding clamp (DnaN) is an innovative target for the development of novel antibiotics, which are urgently needed to overcome the alarming antimicrobial resistance crisis.
In the previous ERC starting grant (NovAnI), we discovered a novel DnaN inhibitor (WAM-N17) with promising broad-spectrum antibacterial activity including multidrug-resistant (MDR) pathogens.
In this PoC project, we will optimize the antibacterial potency and spectrum and characterize the in vivo pharmacokinetic (…
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
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