CORDIS Project
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The ANGIOBLOCK project investigates the role of Neuropilin 1 in preventing abnormal blood vessel growth in age-related macular degeneration. Using a mouse model, it aims to assess the potential of targeting this molecule to reduce vision loss caused by retinal diseases.
Age-related macular degeneration (AMD) is a retinal disease characterized by central vision loss produced mainly by new vessels formed from choroidal capillaries (choroidal neovascularization, CNV).
Current therapies are directed to inhibit angiogenesis by blocking vascular endothelial growth factor (VEGF); however patients need to be retreated given that CNV tends to recur.
Furthermore, not all patients respond equally well to the treatment.
Moreover, sustained blocking of VEGF may have harmfu…
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