CORDIS Project
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This project aims to understand the structure and dynamics of protein networks in human cells, focusing on the kinetochore, a key component for chromosome segregation during cell division. By using advanced mass spectrometry and cryo-electron tomography, it seeks to create a detailed 3D map of the kinetochore's archite…
A mechanistic understanding of a living cell requires the characterization of the architecture and dynamic assembly of its macromolecular complexes.
The proposed project describes a novel integrative approach to determine the topology of protein networks and higher order assemblies using chemical crosslinking, state of the art mass spectrometry (MS) and cryo-electron tomography (cryo-ET).
This MS based strategy will enable the high-throughput detection and integration of structural data of biolo…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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