CORDIS Project
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This project aims to investigate the cellular origins of breast cancer using a novel experimental model. It seeks to clarify how different cell types contribute to the development of various breast cancer subtypes.
Breast cancer is a heterogeneous disease, which includes many different types of cancers with diverse histopathologies, genetic and genomic variations, and clinical outcomes.
Pathological states of the breast, such as pre-neoplastic lesions and carcinomas, retain aspects of cellular composition observed in the normal breast.
It is not clear if the heterogeneity of breast cancer reflects the same hierarchical pattern of the normal tissue.
In particular, the question remains as to whether specific…
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