CORDIS Project
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This project focuses on enhancing the LILBID method to analyze macromolecular complexes with high precision. By optimizing mass spectrometry techniques, it aims to maintain the 3D structure of protein complexes while determining their composition and connectivity, enabling deeper insights into cellular processes.
Crucial processes within cells depend on specific non-covalent interactions which mediate the assembly of proteins and other biomolecules.
Deriving structural information to understand the function of these complex systems is the primary goal of Structural Biology.In this application, the recently developed LILBID method (Laser Induced Liquid Bead Ion Desorption) will be optimized for investigation of macromolecular complexes with a mass accuracy two orders of magnitude better than in 1st genera…
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
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