CORDIS Project
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This project investigates the mechanisms of leukocyte migration across bronchial and alveolar epithelial barriers in the lungs, focusing on their roles in respiratory diseases like pneumonia and pulmonary fibrosis. It utilizes both in vitro human models and animal studies to enhance understanding and develop potential…
Inflammation of the lung is central to the pathogenesis of most respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis (PF), cystic fibrosis (CF) and pneumonia.
Leukocytes traffic through normal lung for immune surveillance; but these numbers increase in response to toxins or pathogens and can be overwhelming.
Leukocytes can exit from the lung interstitium across the bronchial epithelium, into the airway lumen by a mechanism called “luminal clear…
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