CORDIS Project
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This project investigates how elevated ammonia levels during chronic viral infections affect immune responses and tissue damage. By utilizing advanced metabolic analyses and genetic tools, it aims to uncover the signaling roles of ammonia in the body, particularly its impact on sickness behavior and inter-organ communi…
Signaling functions of metabolites have been gathering interest in the context of infection, cancer, and metabolic disorders.
However, how metabolic communication networks shape the pathology of infection remains poorly understood.
Our group has recently reported that chronic infection with lymphocytic choriomeningitis (LCMV) in mice leads to reprogramming of the hepatic urea cycle with a concomitant increase with blood ammonia levels.
Despite being typically considered as a waste product with n…
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