CORDIS Project
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This project investigates the mechanisms of antimicrobial peptides, specifically the dermcidin oligomer, to understand its action on bacterial membranes. By using molecular dynamics simulations, it aims to clarify how these peptides function as potential antibiotics.
Antimicrobial peptides (AMPs) have great potential as a new generation of antibiotics, but their function mechanisms are very elusive which hinders the design and application of this kind of new antibiotics in medicine or therapy.
Different function models have been proposed, one of which is the oligomerization of AMPs and pore formation on the bacterial membranes.
However, there are no atomic structures of AMP oligomers published and therefore no atomic details exist about how they act on membr…
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