CORDIS Project
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This project investigates how specific proteins regulate gene silencing in plants, focusing on the FLOWERING LOCUS C gene in Arabidopsis thaliana. By understanding the interactions between DNA binding proteins and Polycomb proteins, the research aims to clarify the mechanisms of epigenetic memory and gene expression co…
The current lack of mechanistic understanding regarding how Polycomb targets are selected severely limits the potential for epigenetic manipulation in many eukaryotic systems.
This proposal therefore addresses a key central question in chromatin biology: which factors specify a gene for Polycomb mediated silencing?
It will make use of the recent identification of a single nucleotide polymorphism within the target gene that blocks cold induced silencing of the Polycomb switching system at FLOWERI…
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