CORDIS Project
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This study investigates the link between insulin resistance and Alzheimer's disease using Drosophila models. It aims to uncover the mechanisms connecting these conditions and evaluate the role of autophagy in clearing misfolded proteins, potentially leading to new therapeutic strategies.
Alzheimer's disease (AD) is the most common neurodegenerative disorder affecting about 20 million people worldwide.
Although aging is considered to be the most important risk factor for Alzheimer's disease, growing evidence from epidemiological studies suggest that type-2 diabetes (T2DM) increases the risk factor of AD.While compelling evidence establishes a link between insulin resistance and amyloid burden, relationships to tau are far from clear.
In a recent study, it was shown that dysregula…
UNIVERSITY OF SOUTHAMPTON
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