CORDIS Project
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The ALTER-brain project investigates how the brain's microenvironment changes to support cancer metastasis. By studying these alterations, the project aims to develop innovative treatments for brain metastases, focusing on understanding the interactions between different brain cell types and their role in tumor growth.
Organ colonization is the most inefficient step of metastasis.
However, once a few cancer cells manage to re-initiate their growth in the brain, the initial naïve microenvironment, which was not favouring and even actively limiting the number of potential metastasis initiating cells, is slowly rewired into a different ecosystem with pro-metastatic properties.
In this project (ALTER-brain), we will study the biology of microenvironment reprogramming to explore innovative ways of treating metastas…
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