CORDIS Project
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This project aims to identify new therapeutic targets for glioblastoma multiforme by studying the interactions of vascular endothelial growth factor with a novel receptor. It seeks to uncover mechanisms of resistance to existing anti-angiogenic therapies.
Anti-vascular endothelial growth factor (VEGF) therapies, such as bevacizumab, inhibit VEGF angiogenic actions and are increasingly used in the clinic as anticancer regimens for a variety of tumours, among which glioblastoma multiforme (GBM), the most lethal and angiogenic brain tumour, characterized by a high degree of heterogeneity.
However, resistance to anti-angiogenic therapy, which leads to ineffectiveness of the existing drugs, is often acquired and suggests that there is urgent need to i…
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