CORDIS Project
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This project investigates the genetic interactions of key factors in Amyotrophic Lateral Sclerosis (ALS) using zebrafish models. It aims to uncover molecular mechanisms underlying neurodegeneration and identify potential therapeutic targets.
Brain and spinal cord diseases affect 38% of the European population and cost over 800 billion € annually; representing by far the largest health challenge. ALS is a prevalent neurological disease caused by motor neuron death with an invariably fatal outcome. I contributed to ALS research with the groundbreaking discovery of TDP-43 mutations, functionally characterized these mutations in the first vertebrate model and demonstrated a genetic interaction with another major ALS gene FUS.
Emerging e…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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France, PARIS 15
Type: Research institute
Activity type: Research Organisations
SME: No
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