CORDIS Project
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This project explores the allosteric regulation of the CRISPR-Cas9 genome editing system. By utilizing advanced theoretical methods, it aims to uncover the molecular mechanisms of allostery to enhance the efficiency and specificity of genome editing tools.
Allostery is a fundamental property of proteins, which regulates biochemical information transfer between spatially distant sites.
Many emerging allosteric targets are large protein/nucleic acid complexes responsible for genome editing and regulation, whose underlying signaling remains poorly understood.
Here, we focus on CRISPR-Cas9, a large nucleoprotein complex widely employed as a genome editing tool with enormous promises for medicine and biotechnology.
In this system, an intricate alloster…
TECHNISCHE UNIVERSITAET MUENCHEN
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