CORDIS Project
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This project investigates how epigenetic modifications affect the rearrangement of antibody genes in B lymphocytes, focusing on the concept of allelic exclusion. By creating a novel mouse model, it aims to enhance understanding of the immune system's specificity and self-tolerance, with implications for diseases like i…
Antibody genes in B lymphocytes are assembled from multiple rearranging gene segments, enabling the immune system to protect us from a huge diversity of pathogens.
Each B lymphocyte expresses only one antibody specificity on the cell surface (monospecificity), even though there is more than one allele for each antibody chain, a phenomenon termed allelic exclusion.
Allelic exclusion requires asynchronous rearrangement of antibody genes combined with feedback inhibition to prevent the assembly of…
FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
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