CORDIS Project
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This project focuses on developing a new method for synthesizing non-natural α-amino acids using gold catalysis. It aims to create enantiopure α-amino acids efficiently from simple alkenes, with applications in therapeutics and chemical biology, while also exploring new techniques for modifying peptides and proteins.
This proposal centres on using cutting edge organic synthesis as a tool for the investigation of chemical biology.
The first section deals with development of a novel, expedient and efficient approach to the synthesis of non-natural α-amino acids.
This will employ gold catalysis to enable a completely regio- and enantioselective amino-oxygenation of an alkene to give an enantioenriched α-amino acid after simple oxidation.
This method will allow highly direct access to enantiopure α-amino acids f…
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