CORDIS Project
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This project aims to investigate acute respiratory distress syndrome (ARDS) using mesenchymal stem cell-derived extracellular vesicles as a potential therapy. By studying the biological differences between ARDS endotypes, the research seeks to understand how these vesicles can improve treatment outcomes.
Acute respiratory distress syndrome (ARDS) is a major cause of mortality in the critically ill patients with no effective pharmacological treatment.
Recently, two distinct endotypes of ARDS were identified and validated in four large randomized controlled trials: a hyper-inflammatory and a hypo-inflammatory endotype.
These endotypes have strikingly different clinical characteristics, biomarker profiles, clinical outcomes, and treatment responses.
While these data are highly promising, the biolog…
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