CORDIS Project
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This project focuses on synthesizing sulfolipid-I, a key component of the Mycobacterium tuberculosis cell wall, to understand its role in antibiotic resistance. The aim is to develop a streamlined method for producing this complex molecule to facilitate further research into its biological activities.
Mycobacterium tuberculosis, the causative agent of human tuberculosis, is unique among bacterial pathogens.
Sulfolipid-I (SL-I) is the major constituent metabolite of thick cell wall present in Mycobacterium Tuberculosis (M-TB). SL-I comprises of a disaccharide and four chiral hydrophobic lipid substituents, the overall structure of which is responsible for the resistance of M.
Tuberculosis to antibiotics.
While SL-I has been shown to elicit specific responses from immune cells, the mechanistic…
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