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AL2BIOCH focuses on understanding the architecture of Polyketide Synthases, which are crucial for producing diverse natural products like antibiotics. The project employs advanced imaging techniques to study the assembly and function of these biosynthetic systems.
Polyketide Synthases (PKS) are biological factories for the production of potent natural products, including antibiotics, anti‐cancer drugs, statins and further drugs.
The exceptional chemical diversity generated by PKS is encoded in their modular architecture.
The domains required for one step of precursor elongation and modification are combined into a functional polypeptide module. PKS modules can either act iteratively (iPKS) or in a linearly organized assembly line of multiple modules (modP…
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