CORDIS Project
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This project focuses on the role of Topoisomerase 2a in T cell education and autoimmunity. It aims to understand how this protein interacts with the Autoimmune regulator gene and its potential to reverse autoimmune conditions in model organisms.
In a functional immune system, T cells serve as potent immunologic weapons, attacking foreign invaders, while tolerating the body’s own components.
Unfortunately, these beneficial weapons can occasionally turn against self and attack the body’s own organs, resulting in autoimmunity.
One of the most common reasons for this phenomenon is that the body fails to properly educate T cells on how to distinguish between self and non-self (foreign invader).
These mis-educated cells then remain in the bod…
WEIZMANN INSTITUTE OF SCIENCE
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