CORDIS Project
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This project aims to develop predictive models of gene regulation using deep learning and single-cell genetic screens. By exploring synthetic gene regulatory elements and networks in hematopoietic stem cells, it seeks to enhance our ability to design targeted gene regulation for biomedical applications.
Our abilities to predict and engineer complex biological systems are in their infancy.
In the context of gene regulation, we cannot design artificial promoters with specificity to arbitrary cell states, and we cannot arbitrarily trans- and de-differentiate somatic cells, although such abilities would be of high biotechnological and biomedical value.
To achieve these ambitious goals, we require quantitative, predictive models of gene regulatory elements (GREs) and gene regulatory networks (GRNs),…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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