CORDIS Project
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This project aims to discover new drug leads for malaria by utilizing artificial intelligence to guide virtual screening of large chemical libraries targeting the P. falciparum dihydroorotate dehydrogenase enzyme. The approach seeks to enhance drug efficacy against resistant strains by identifying compounds that are bo…
Malaria, a global infectious disease, is facing a critical issue of drug efficacy loss due to the alarming rise of antimicrobial resistance (AMR).
To combat this, a promising strategy is the discovery of cell-active drug leads hitting new targets, such as P. falciparum dihydroorotate dehydrogenase (PfDHODH).
However, two main roadblocks prevent us from achieving this important goal: 1) many molecules with potent activity on a protein target are later found to be inactive in pathogen cultures for…
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