CORDIS Project
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This research investigates how mutations in proteins can lead to a new form of self-assembly called agglomeration, which differs from traditional aggregation. The study aims to understand its implications for cell physiology and its potential role in diseases like sickle-cell anemia.
Understanding how proteins respond to mutations is of paramount importance to biology and disease.
While protein stability and misfolding have been instrumental in rationalizing the impact of mutations, we recently discovered that an alternative route is also frequent, where mutations at the surface of symmetric proteins trigger novel self-interactions that lead to infinite self-assembly.
This mechanism can be involved in disease, as in sickle-cell anemia, but may also serve in adaptation.
Impor…
UNIVERSITE DE GENEVE
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Israel, Rehovot
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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