CORDIS Project
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This project investigates how the development of dendritic cells in early life influences immune balance. By examining the differences between neonatal and adult dendritic cells, the research aims to uncover the mechanisms that regulate immune responses during critical developmental stages.
Early life immune balance is essential for survival and establishment of healthy immunity in later life.
We aim to define how age-dependent regulation of dendritic cell (DC) development contributes to this crucial immune balance. DCs are versatile controllers of immunity that in neonates are qualitatively distinct from adults.
Why such age-dependent differences exist is unclear but newborn DCs are considered underdeveloped and functionally immature.
Using ontogenetic tracing of conventional DC p…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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