CORDIS Project
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This project investigates how the accessory genome of Pseudomonas aeruginosa contributes to persistent infections in cystic fibrosis patients. By employing CRISPR-Cas tools, the research aims to identify gene transfer events and assess the impact of accessory genes on bacterial survival during lung infections.
Bacterial survival to antibiotic treatment poses an urgent problem to humanity, causing 25.000 deaths per year in the European Union alone.
The inability to fully eradicate pathogens with antibiotics leads to the establishment of persistent infections (PIs).
Pseudomonas aeruginosa, an opportunistic pathogen, is found chronically in the airways of 70% of Cystic Fibrosis (CF) patients.
In CF, the anomalous production of mucus in the lung promotes the establishment of bacteria, with infections decr…
TECHNICAL UNIVERSITY OF DENMARK DTU
DANMARKS TEKNISKE UNIVERSITET
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