CORDIS Project
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This project focuses on understanding the structural biology of G protein-coupled receptors (GPCRs) to improve drug design. It aims to elucidate the interactions between specific GPCRs and their protein ligands using advanced crystallography techniques.
G protein-coupled receptor (GPCR) proteins are the single largest drug target, representing 30% of all marketed drugs.
All GPCRs share a basic structural core of seven transmembrane alpha-helical domains.
In spite of this similarity, GPCRs have evolved to be extremely versatile receptors for extracellular messengers as diverse as biogenic amines, purines and nucleic acid derivatives, lipids, peptides and proteins, odorants, pheromones, tastants, ions like calcium and protons, and even photons. D…
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
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