CORDIS Project
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This project investigates the genetic factors associated with late-onset Alzheimer's Disease by analyzing 98 genetic loci and their relationship with brain degeneration. It aims to identify protective genetic variants and distinct Alzheimer's subtypes to develop targeted therapies.
The list of genes contributing to increased risk of developing Alzheimer’s Disease (AD) grows every year.
To date, large case-control Genome-Wide Association Studies have found 98 genetic loci associated with late-onset Alzheimer's Disease (LOAD).
However, apart from a small number of genes related to familial cases, it remains largely unknown the direct relationships between genes amyloid-β and tau misfolding protein accumulation (hallmark of AD), and neurodegeneration of the human brain.
Even…
ASOCIACION INSTITUTO DE INVESTIGACION SANITARIA BIOBIZKAIA
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