CORDIS Project
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This project investigates the role of AMPA glutamate receptors in synaptic transmission and plasticity, focusing on their organization and dynamics in the brain. By combining advanced imaging techniques with molecular biology, it aims to uncover mechanisms that affect learning, memory, and cognitive disorders.
AMPA glutamate receptors (AMPAR) play key roles in information processing by the brain as they mediate nearly all fast excitatory synaptic transmission.
Their spatio-temporal organization in the post synapse with respect to presynaptic glutamate release sites is a key determinant in synaptic transmission.
The activity-dependent regulation of AMPAR organization is at the heart of synaptic plasticity processes underlying learning and memory.
Dysfunction of synaptic transmission - hence AMPAR organ…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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