CORDIS Project
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This research explores the maturation of inhibitory signaling in neonatal spinal networks, focusing on specific interneurons that modulate touch sensitivity. By identifying the mechanisms driving this maturation, the project aims to enhance understanding of sensory processing in infants, particularly in intensive care…
In the early postnatal period neonates are particularly sensitive to touch, often responding with exaggerated reflexes and whole-body movements to an isolated cutaneous stimulus.
This suggests a predominance of excitation over inhibition in spinal sensory networks, which may facilitate activity-dependent synaptic strengthening.
We have recently shown that neonatal hypersensitivity to touch is due to the late maturation of glycinergic inhibitory signalling and that this signalling, in turn, requi…
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