CORDIS Project
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This project introduces a method called 'pathway swapping' to redesign the metabolic networks of microbes for industrial applications. By relocating genes responsible for central carbon metabolism to a synthetic chromosome, it aims to enhance the efficiency of engineered microbes in bio-based processes.
Replacement of petrochemistry by bio-based processes is key to sustainable development and requires microbes equipped with novel-to-nature capabilities.
The efficiency of such engineered microbes strongly depends on their native metabolic networks.
However, aeons of evolution have optimized these networks for fitness in nature rather than for industrial performance.
As a result, central metabolic networks are complex and encoded by mosaic microbial genomes in which genes, irrespective of their f…
TECHNISCHE UNIVERSITEIT DELFT
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