CORDIS Project
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This project investigates the interactions of the A2A-adenosine receptor with various accessory proteins in living organisms. By utilizing a two-step proteomics approach, the research aims to identify and characterize these interactions, potentially setting a new standard for studying G protein-coupled receptors.
The A2A-adenosine receptor is a Gs-coupled receptor, which has several unique structural and functional characteristics.
Recently, the C-terminus of the receptor has been appreciated as a binding site for several “accessory” proteins, of which only half a dozen are established.
It is clear that (i) this list cannot be exhaustive and (ii) that all these proteins cannot bind simultaneously to the receptor.
The challenging, but very important task is to document which of all these interactions do o…
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