CORDIS Project
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This project investigates the role of the enzyme dipeptidyl peptidase-4 (DPP-4) in obesity and insulin resistance. By creating a mouse model lacking adipose DPP-4, it aims to clarify its impact on metabolic syndrome and glucose regulation.
Dipeptidyl peptidase-4 (DPP-4) is an exoprotease that cleaves N-terminal dipeptides from several substrates such as glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GLP), impairing the function of the incretin system, which is of key importance for glucose homeostasis.
Indeed, DPP4 inhibitors are currently in clinical use for type 2 diabetes.
The host group has described for the first time that DPP4 is secreted by adipose and strongly correlates with adipocyte volume and param…
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