CORDIS Project
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This project aims to understand the molecular dynamics of immune cell interactions during antibody-mediated killing of diseased cells. By imaging immune synapses, it seeks to optimize engineered antibodies for enhanced therapeutic efficacy against diseases like cancer.
High-resolution microscope images of immune cells contacting other cells have revealed temporary membrane structures, often called immune synapses (IS).
Proteins commonly segregate into specific regions at the contacts between cells, and exploring how such changing arrangements of proteins occur and how they control immune cell communication is the new science opened up by the immune synapse concept.
Over the last decade the use of monoclonal antibodies has revolutionised the treatment of severe…
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