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The AdaptiveSTED project aims to enhance super-resolution microscopy by developing real-time aberration correction techniques. This will improve imaging quality in complex biological samples, allowing for better visualization of structures at the molecular level.
Super-resolution methods have recently given new life to fluorescence microscopy; they promise molecular-scale resolution, while maintaining all the benefits of traditional diffraction limited techniques, such as robust labeling methods and three-dimensional imaging capability.
However, the current super-resolution techniques only work reliably with thin, brightly labeled, low background samples. STimulated Emission Depletion (STED) super-resolution microscopy in principle is exceptionally well…
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
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