CORDIS Project
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This project investigates how redox adaptation is regulated during macrophage activation, focusing on the roles of specific transporters and regulators. By understanding these mechanisms, the research aims to identify new drug targets for treating conditions related to oxidative stress and improve pathogen defense stra…
Macrophages are key players of the innate immune system and as such maintain homeostasis, initiate inflammatory and redox responses for pathogen defence, but also regulate resolution of inflammation.
Supporting these functions are distinct metabolic programmes, which underlie macrophage functional phenotypes.
While recent advances have improved the understanding of macrophage metabolic programmes supporting specific activation states, it remains unclear how the redox system is regulated in macro…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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