CORDIS Project
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This project investigates the role of ADAM10, a potential enzyme involved in Alzheimer’s disease, by studying its activity in brain cells and its impact on amyloid-β peptide production. The research aims to uncover regulatory factors affecting ADAM10 and explore its implications for neurodegeneration and cognitive func…
With life expectancy increasing rapidly in our Western world, Alzheimer’s disease (AD), a progressive neurodegenerative disorder resulting in dementia, is becoming more common, however no cures or effective treatments are currently available.
The neurotoxic amyloid-β (Aβ) peptide appears central to AD pathogenesis, and is generated by β- and γ-cleavage of the larger amyloid precursor protein (APP). APP can also be cleaved by α-secretase, which cleaves within the Aβ peptide region and hence precl…
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