CORDIS Project
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This project investigates a novel treatment for Alzheimer's disease by using a specific nanobody to inhibit the BACE1 protein, which is linked to amyloid plaque formation. The delivery system utilizes a virus that can cross the blood-brain barrier, aiming to enhance therapeutic efficacy.
Alzheimer’s disease (AD) is the most common form of dementia in the Western World, representing an economic and social cost of billions of euros a year.
Given the changing demographics of society, these costs will only increase over the coming decades.Amyloid plaques, composed of amyloid beta peptide (Abeta), are a defining characteristic of AD.
Evidence now suggests that Abeta is central to disease pathogenesis due to its toxicity, which leads to cell loss and eventual cognitive decline.
Abeta…
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