CORDIS Project
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This project investigates the virulence mechanisms of the human pathogen Acinetobacter baumannii using the amoeba Acanthamoeba castellanii as a model. It employs large-scale screening methods to identify virulence factors and assess bacterial resistance during amoebal predation, utilizing advanced imaging and genetic t…
The human pathogen Acinetobacter baumannii represents a deadly threat to human health.
Despite its established clinical relevance, the pathogenicity of this nosocomial superbug is poorly understood.
The biphasic amoeba Acanthamoeba castellanii is a cellular infection model broadly used to decipher the virulence mechanisms of human pathogens, as bacterial resistance upon amoebal predation (grazing) are often correlated with their pathogenicity potential in human.
However, high-throughput screenin…
UNIVERSITE DE NAMUR
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